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Tobacco plants now produce psilocybin and DMT — on purpose

Ellsworth Toohey
Apr 02, 2026
∙ Paid

Wacky tobacky (Piyawat Nandeenopparit/shutterstock.com)

Researchers at the Weizmann Institute of Science in Israel have modified tobacco plants to yield five psychedelic compounds at once: bufotenin and 5-MeO-DMT (from Colorado River toad secretions), DMT (a tryptamine found across plant species), and psilocin and psilocybin (normally found in mushrooms)…

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