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500+ brain scans reveal what LSD, psilocybin, DMT have in common

Ellsworth Toohey
Apr 08, 2026
∙ Paid

Room27/Shutterstock

Psilocybin, LSD, mescaline, DMT, and ayahuasca have different chemical structures, different durations, different cultural histories — and they all do the same thing to the brain. A mega-analysis published in Nature Medicine found a shared two-part pattern across all five drugs: normally tight neural networks weaken internally, while …

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